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中国癌症防治杂志

中国癌症防治杂志 ›› 2012, Vol. 4 ›› Issue (2): 187-190.doi: 10.3969/j.issn.1674-5671.2012.02.22

• 流行病学研究 • 上一篇    下一篇

479例肝细胞癌先证者家族聚集性分析

  

  1. 广西医科大学附属肿瘤医院肝胆外科；广西医科大学研究生学院
  • 出版日期:2012-06-25 发布日期:2012-07-03
  • 通讯作者: 黎乐群 E-mail:li_lequn@263.net
  • 基金资助:

    广西壮族自治区卫生厅重点科研课题 （重 200975）

Familial aggregation in first-degree relatives of 479 probands with hepatocellular carcinoma

  • Online:2012-06-25 Published:2012-07-03

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被引次数

15

摘要： 目的 通过肝细胞癌（HCC）先证者一级亲属发病调查情况，探讨HCC病例分布的家族聚集性的特点。方法 应用临床流行病学横断面研究方法，对2004～2008年广西医科大学附属肿瘤医院HCC先证者家系中一级亲属HCC发病情况进行调查，回顾性采用Poisson（泊松） 分布模型拟合，并用频数分布拟合优度的X2检验进行验证。对有家族史的HCC分布用二项分布（p+q）n模型拟合。HCC分离比采用 Li-Mantel-Gart法估算。结果 HCC先证者479例，占住院人数16.91%（479/2 832）。该家族中实际病例数分布超越了二项分布的概率范围（P =0.028）。HCC的分离比为0.04，分离比方差为0.000 015 09，标准误为0.003 885，95%可信限区间：0.033 784～0.046 216。结论 HCC发病具有家族聚集现象，主要集中在一级亲属，HCC的遗传方式为多基因遗传，HCC先证者家系是HCC发病的危险因素之一。 

关键词: 肝肿瘤, 临床流行病学, 横断面研究, 二项分布

Abstract: Objective To investigate the prevalence of hepatocellular carcinoma（HCC）among first-degree relatives and explore the familial aggregation of HCC. Methods A cross-sectional study was performed on first-degree relatives of HCC probands treated at the Affiliated Cancer Hospital of Guangxi Medical University from 2004 to 2008.The binomial distribution model was applied to test the goodness-of-fit of the frequency distribution.Results There were 479 probands，accounting for 16.91%（479/2 832） of hospital admis-sions. Results of binominal distribution analysis showed that the number of HCC cases within proband families was significantly higher than the theoretical range（P=0.028）.The estimated separation ratio of HCC was 0.04，and the separation ratio variance was 0.000 015 09（SD=0.003 885，95%CI： 0.033 784～0.046 216）. Conclusion HCC shows significant familial aggregation in first-degree relatives of probands，and family history is one of the important risk factors for HCC. 

Key words: Liver neoplasms, Clinical epidemiology, Cross-sectional study, Binomial distribution